Imaging latent tuberculosis infection with radiolabeled nitroimidazoles

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Imaging latent tuberculosis infection with radiolabeled nitroimidazoles.

In a previous paper, an overview of the use of PET/CT in the management of tuberculosis (TB) was provided and the potential role of nitroimidazole imaging in LTBI was considered [1]. During latent TB, dormant bacilli putatively reside in a hypoxic environment of caseating lung granulomas. Exposure of Mycobacterium tuberculosis (Mtb) to progressive hypoxia in vitro induces a dormant state charac...

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Tuberculosis Infection and Latent Tuberculosis

Active tuberculosis (TB) has a greater burden of TB bacilli than latent TB and acts as an infection source for contacts. Latent tuberculosis infection (LTBI) is the state in which humans are infected with Mycobacterium tuberculosis without any clinical symptoms, radiological abnormality, or microbiological evidence. TB is transmissible by respiratory droplet nucleus of 1-5 µm in diameter, conta...

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Tuberculosis and Latent Tuberculosis Infection

22. Paradise JL, Bluestone CD, Colborn DK. Adenoidectomy and adenotonsillectomy for recurrent acute otitis media: parallel, randomized, clinical trials in children not previously treated with tympanostomy tubes. JAMA. 1999; 282:945-953. 23. Darrow DH, Siemens C. Indications for tonsillectomy and adenoidectomy. Laryngoscope. 2002;112(8 pt 2, suppl 100):6-10. 24. Hammaren-Malmi S, Saxen H, Tarkan...

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Evaluation of Interleukin17and Interleukin 23 expression in patients with active and latent tuberculosis infection

Objective(s): Tuberculosis is one of the most important infectious diseases with high mortality rates worldwide, especially in developing countries. Interleukin17 (IL-17) is an important acquired immunity cytokine, which is mainly produced by CD4+TH17 cells. It can recruit neutrophils and macrophages to the infected site in the lungs. IL-23 is one of the most important inducers of IL-17. In the...

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Latent Tuberculosis Infection

• Objective: To review the diagnosis and treatment of latent tuberculosis infection (LTBI). • Methods: Qualititative assessment of the literature. • Results: One third of the world’s population is latently infected with Mycobacterium tuberculosis. From this pool, approximately 9 million active tuberculosis (TB) cases emerge annually, resulting in 2 to 3 million deaths and making TB the most com...

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ژورنال

عنوان ژورنال: Clinical and Translational Imaging

سال: 2016

ISSN: 2281-5872,2281-7565

DOI: 10.1007/s40336-016-0166-y